Synthesis and Antithyroidal Evaluation of N–Aryl Formamidino–N–(Substituted) Aryl Thiocarbamides

Swati Pawar

doi:https://doi.org/10.51976/ijari.211404

Submit Manuscript Login / Register Subscribe

Home Page

Editorial Advisory Board

Mission, Aims & Scope

Current Issue

Synthesis and Antithyroidal Evaluation of N–Aryl Formamidino–N–(Substituted) Aryl Thiocarbamides

Swati Pawar

Vol 2 , Issue 1 , January - March 2014 | Pages: 25-35 | Research Paper

https://doi.org/10.51976/ijari.211404

Received: January 01, 2014 | Revised: February 20, 2014 | Accepted: February 28, 2014 | Published Online: March 15, 2014

Author Details ( * ) denotes Corresponding author

1. * Swati Pawar, Department of Applied Science, BIT, National Capital Region, Ghaziabad, Uttar Pradesh, India (Pawar.swati05@gmail.com)

Several N–aryl formamidino derivatives of thiocarbamides were synthesized. The structure and purity of the prepared compounds were characterized by elemental, spectral (IR) and TLC analysis. These molecules were evaluated for their efficacy as antithyroidals by radioactive iodine uptake method & the activity (Potency) of synthesized compounds were compared with standard drug Thiouracil.

Keywords

Thiocarbamides; Antithyroidal Activity; Toxicity

A. K. Mukherjee, R. Ashare, Chemical reviews, 1991– Pubs. acs. Org

Werner Sc., A history of thyroid. Philadelphia, P.A.: Lippincott. 1991

Klein, Ujamaak, Thyrotoxicosis and the Endocrinol Metab clin N Am. 27: 51-62, 1998

Savu Ria, Vranckx, Roger, Mayu, Michelle Gripoves, Daniel, Blouquit, Marie, France, Nunez, Emmarual, A, Biochem. Biophys, Acta., 992 (3) 379-384 (Eng) (1989)

Murthy, G. Rama, A. Bhasker, Rao, V. Malla Reddy, Indian Drugs 24 (2), 92-93, 1987

J. S. Upadhyaya, P. K. Srivastava, W. U. Malik, Egypt J. Chem., 25 (1), 75, 1982 (Pub., 1983)

M. E. Abdullah, H. Y. Abdul, Enein, M. M. A. Hassan, S. A. Taha, Proc. Inst. Symp. Appl. Technol. Ioniz., Radiat. 1982 (Pub. 1983), 1, 53, – 7 (Eng.)

Gilles Gossellin, Jean Louis Imbach, Leroy, B. Townsend, Raymond, P. Panzica, J. Heterocycl. Chem. 16(6), 1185-1192, 1979 (Pb. 1980)

P. K. Srivastava, M. B. Gupta, H. D. Mishra, Sup. J. Med. Chem. Chim, Ther, 15 (2), 147, 1980

Prakash, Rajeev, N. Lakshmipathi, V. Behari, M.K. Chorra, H. Singh, Ind. J. Med. Res., 83, 587-590, 1986

Blank, S. Margot, Joseph R. Tuccu, Arch. Intern. Med., 147 (5), 863-864, 1987

Jambut- A.b Sil, A. C. Buxeraud, J. Raby. C ‘J. Pharm. clin. (1986), 5 (4), 359-75

Mashio, Yasuo, Mutsuo, Biniko, Akemi Ikota, Hiroaki, Hizumoto, Haruhiko Kunito, Acta Endocrinol, 110 (1), 139-144 (1988)

Valeavi, R.V. Jorden, C., Diequez, R., John, E. Manicardi, I, Portjoli, M.D., Rodrigues, Arnao A., Gomez-PAN, R. Hall, M. F. Scanlon, Clin. Endocrinol, 24 (6), 693-698, 1986