Journal Press India^®

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The purpose of writing this review on microspheres is to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. Microsphere promises to be a potential approach for gastric retention. Floating drug delivery systems are designed for the poorly soluble, unstable and locally acting drugs in the G.I.T and they have low bulk density than the gastric content also they float in the stomach for a prolonged period of time. From this the designing of floating microspheres is one of the approach in delivering a dosage form to the target site in sustained controlled release fashion, to achieve good peak plasma concentration by increasing bioavailability of drug or dosage form. In the floating microspheres, the drug loaded microspheres come in contact with gastric fluid the gel formers, and polymer hydrates to form a colloidal gel barrier then controls the rate of fluid penetration into the device and consequent drug released by the swollen polymer lowers the density and float in the stomach.

Keywords

FDDS; Floating Microspheres; Sustained Release; Gastric Emptying Time

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