Acute Toxicity (Lethal Dose 50 Calculation): Medicine as a Life Saver or Destroyer

Malvika Chaudhary; Alka; Sajid Ali

doi:https://doi.org/10.51976/ijari.731902

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Acute Toxicity (Lethal Dose 50 Calculation): Medicine as a Life Saver or Destroyer

Malvika Chaudhary, Alka , Sajid Ali

Vol 7 , Issue 3 , July - September 2019 | Pages: 7-10 | Research Paper

https://doi.org/10.51976/ijari.731902

Received: May 13, 2019 | Revised: June 20, 2019 | Accepted: July 28, 2019 | Published Online: September 15, 2019

Author Details ( * ) denotes Corresponding author

1. * Malvika Chaudhary, Department of Applied Sciences, Delhi Technical Campus, Greater Noida, Uttar Pradesh, India (malvika.phd@gmail.com)

2. Alka Department of Applied Sciences, Delhi Technical Campus, Greater Noida, Uttar Pradesh, India

3. Sajid Ali, Department of Applied Science & Humanities, Krishna Engineering College, Mohan Nagar, Ghaziabad, Uttar Pradesh, India

Lethal dose (LD 50) has been calculated. Different-testing methods have been used. The observed values have been plotted by Dose-Response against measured response & dose. Different LD value shows that all substances are poison. It depend on the amount of dose whether a substance is poison or remedy. In Our research paper we will discuss the different doses, their routes of administration, Lethal, Chronic & Acute toxicity on rats & mice. For the calculation of LD50, Hodge, Sterner, Gosselin, Smith & Hodge scale was used. In this study, different doses (about 10 to 10,000 mg/kg) of the extract were administered by different route to the different groups of rats and mice. Experiments were carried out to observe the toxicity & possible death of animal like rat & mice continuously for 24 hour to calculate LD50 for different drugs.

Keywords

Median Lethal Dose (LD50); Acute & Chronic Toxicity; Dose Response Complexities.

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